Dear Colleague, Thanks for joining this blog. Elsa Baumeister and Daniel Cisterna in Buenos Aires, and Gustavo Palacios and I in New York, look forward to your questions, comments and insights. Happy hunting!
Thanks for making these sequences available! Have you noticed that 8574-Argentina-2009-S4-HA-41 shares a polymorphism with A/Sao Paulo/43812/2009, which was isolated from the first confirmed fatality (11F) in Sao Paulo?
What is really going on is that the entire planet is surrounded by an advanced civilization and this may explain this outbreak of influenza and it's ability to spread to every corner of the world so quickly and also to mutate so quickly as well. This is not a biological attack in the normal sense of what is perceived by humans upon earth. This is post is dead serious. When Jesus Christ was born upon this earth, it was in fact a recreation that has been going on for billions of years in our universe. He passed his "cup" in the Mount of Olives to Mary Magdalene, blood of advanced civilization, all it the Disciples of Christ and that blood is still on this planet, such as myself and will gladly invite anyone to my house to witness first hand for themselves. What is our purpose, our purpose is delivering Revelation upon this planet and also to acquire settlement lands in the Northern Hemisphere. The global financial markets shall collapse the week of 8/3 and the week of 8/10, Russian and U.S. advanced warning systems shall see Wormwood approaching earth. Your attempts to sequence this virus are futile since it is mutatable and very fast rates beyond the capability of your technology to sequence it or produce vaccines for it. A killer mutation shall be discovered and over two billion lives upon this planet are at risk. Again, as sworn upon the Holy Bible and in the eyes of our Lord Jesus Christ, this is not a prank, joke or a demented person posting to this blog. Evaluate the global financial collapse the week of 8/3. We only require Harper, Obama and Putin to attend and meet on our representative on earth to start the negotiating process and we shall end this pandemic plague gripping the entire globe. My birth name is Edward J. Klinard. And ye shall learn to walk through the narrow gate as a humbled man or thou shall face the full wrath of our Lord Jesus Christ.
seems that all are the CancunA-virus with the typical 11 Cancun mutations. The same strain that caused so few deaths in New York. Some "contaminations" with A/CA/04 ? Or maybe I didn't convert correctly
ahh, I see the order of the viruses is nonconstant over the segments, so presumable no contamination/reassortment with CA/04 as I first thought. So just all Cancun viruses will check again
OK, I finally converted it to my format. 11 viruses, all with the 11 Cancun-mutations, all with one additional C1263T mutation in PA if I made no mistake
so, now that we have some genomes and the genetical background, it should be sufficient to occasionally check for new sequences only in a small portion to check presence of one of the 12 markers. (supposedly easier and cheaper ?!) If the marker isn't found then it's a new substrain and they might check the whole new sequence...
do we have patient data of the sequences ? gender,age,location,date,severety of disease
yes, niman A1281G(4) is in sequence 8574 as well as in Sao Paulo/43812 and some other meflu sequences. This is a bit unusual but such things happen with other positions too. e.g. G1173A(4) which happens in the New Jersey strain and in the unrelated Texas-strain. Coincidence ? RNA-constraints ? I have the feeling that it's not so often but still too often to be merely random.
recombination ? hardly. We need double infection for that which is rare in this stage of the pandemic
Dual infections are quite common and sequences are "consensus" sequences (which exclude minor variants). The three polymorphisms in the Sao Paulo sequence trace to three different origins, and the synonymous polymorphism is in 8574-Argentina-2009-S4-HA-41.
One of the Argentina sequences, 9576-Argentina-2009-S3-PA-6, has an adjacent polymorphism, A1287G, which is found in a long list of avian and a few swine sequences, which largely match the list for C1263T, supporting acquistion via homologous recombination. Since, like C1263T, the list is long, I am just posting the link to the sequences, which is rather compelling.
The Argentina sequence with PA A1287 is 8019-Argentina-2009-S3-PA-2 (incorectly stated in preceding post). Donor sequences which have C1263T and A1287G and exactly match the Argentina sequence at all postions between the two polymorphisms are:
I got them from a link at FT, no registration, no restriction/agreement.
Now I read:
---------------- Given that these are draft (i.e., preliminary) data, and are subject to change, I agree not to forward the draft (i.e., preliminary) data to third parties, but will instead direct them to the website.
I am very grateful for your making these sequences from Argentina available so soon.
They are offering compelling study for myself and many others that will promote a beneficial accumulation of knowledge on the South American specimens and potentially the next wave in the Northern Hemisphere. Early data allows deeper analyses. Deeper analyses drive better collection and collaboration efforts.
Please continue to publish as available. Your academic generousity is presently yielding insight and allowing a more robust dataset for our team.
When do you expect to extend the data? Will you have clinical data or category identifiers at any point? Will you create a new dataset with the accumulated sequences or publish incremental updates?
Thank you for the sequences. Sensible researchers are benefiting.
Dear colleagues, Thanks a lot for your comments and insights. We will be adding more sequences in the following days. We are still processing samples and isolates from the more severe cases of the outbreak in Argentina. I hope to fix the link to the PB1 link ASAP.
Thanks for the update. Are most of the samples from severe/fatal cases in the Buenos Aires / Santa Fe provinces, or do they cover a broader geographical area? The finding of C1263T in all PA sequences was a bit surprising.
Extending Dr. Niman's request, would you mind examining the links to NP, PA, PB1 and PB2 on the text based Alignment outcomes? Each of these appears to present the same Segment 7 results.
I begin to speculate that your team may focus on "universal" vaccine targets?
A third PA polymorphism, G1761A, is in 8019-Argentina-2009-S3-PA-2 and that polymorphism is also in many of the avian isolates with the C1263T and A1287A as well as the Candian swine (see list at link below), leaving little doubt that these polymorphisms were acquired by recombination.
The CDC sequences were from isolates collected in mid-June and the sample numbers of the sequence released here suggest these sequences are also from mid-June, but most of the confirmed deaths in Argentina were in July. Are sequences from these July fatal cases going to be posted here soon?
Well, maybe neighboring countries will publish something or travelors from Argentina are sequenced elsewhere.
Or scientists publishing from Argentina need to keep it secret until publishing, so it remains exclusive. I don't understand how that works but we often see that. That could give 6 months - 2 years delay until a paper is published in a journal and typically the sequences are published then at genbank. Too late for this coming wave.
Thanks for making these sequences available! Have you noticed that 8574-Argentina-2009-S4-HA-41 shares a polymorphism with A/Sao Paulo/43812/2009, which was isolated from the first confirmed fatality (11F) in Sao Paulo?
ReplyDeleteHere is a fuller set of sequences that match
ReplyDeletegb|GQ414768.1| A/Sao Paulo/43812/2009
gb|GQ377095.1| A/California/24/2009
gb|GQ359765.1| A/Stockholm/31/2009
gb|GQ292961.1| A/Mexico City/22/2009
gb|GQ229293.1| A/swine/Hong Kong/NS1659/2001
gb|GQ232085.1| A/Guangdong/02/2009
gb|GQ223435.1| A/Guangdong/05/2009
gb|GQ132144.1| A/Canada-ON/RV1529/2009
What is really going on is that the entire planet is surrounded by an advanced civilization and this may explain this outbreak of influenza and it's ability to spread to every corner of the world so quickly and also to mutate so quickly as well. This is not a biological attack in the normal sense of what is perceived by humans upon earth. This is post is dead serious. When Jesus Christ was born upon this earth, it was in fact a recreation that has been going on for billions of years in our universe. He passed his "cup" in the Mount of Olives to Mary Magdalene, blood of advanced civilization, all it the Disciples of Christ and that blood is still on this planet, such as myself and will gladly invite anyone to my house to witness first hand for themselves. What is our purpose, our purpose is delivering Revelation upon this planet and also to acquire settlement lands in the Northern Hemisphere. The global financial markets shall collapse the week of 8/3 and the week of 8/10, Russian and U.S. advanced warning systems shall see Wormwood approaching earth. Your attempts to sequence this virus are futile since it is mutatable and very fast rates beyond the capability of your technology to sequence it or produce vaccines for it. A killer mutation shall be discovered and over two billion lives upon this planet are at risk. Again, as sworn upon the Holy Bible and in the eyes of our Lord Jesus Christ, this is not a prank, joke or a demented person posting to this blog. Evaluate the global financial collapse the week of 8/3. We only require Harper, Obama and Putin to attend and meet on our representative on earth to start the negotiating process and we shall end this pandemic plague gripping the entire globe. My birth name is Edward J. Klinard. And ye shall learn to walk through the narrow gate as a humbled man or thou shall face the full wrath of our Lord Jesus Christ.
ReplyDeleteseems that all are the CancunA-virus with the
ReplyDeletetypical 11 Cancun mutations.
The same strain that caused so few deaths in New York.
Some "contaminations" with A/CA/04 ? Or maybe I didn't convert correctly
ahh, I see the order of the viruses is
ReplyDeletenonconstant over the segments, so presumable no contamination/reassortment with CA/04 as I first thought. So just all Cancun viruses
will check again
I have
ReplyDelete7937,7953,7967,7980,8019,8574,9588,9597,9711
OK, I finally converted it to my format.
ReplyDelete11 viruses, all with the 11 Cancun-mutations,
all with one additional C1263T mutation in PA
if I made no mistake
mutation table here:
http://www.flutrackers.com/forum/showthread.php?p=274732
so, now that we have some genomes and the genetical background,
ReplyDeleteit should be sufficient to occasionally check for new sequences
only in a small portion to check presence of one of the 12 markers.
(supposedly easier and cheaper ?!)
If the marker isn't found then it's a new substrain and they
might check the whole new sequence...
do we have patient data of the sequences ?
gender,age,location,date,severety of disease
yes, niman A1281G(4) is in sequence 8574 as well as in Sao Paulo/43812
ReplyDeleteand some other meflu sequences.
This is a bit unusual but such things happen with other positions too.
e.g. G1173A(4) which happens in the New Jersey strain and in the unrelated Texas-strain.
Coincidence ? RNA-constraints ? I have the feeling that it's not so often but still
too often to be merely random.
recombination ? hardly. We need double
infection for that which is rare in this
stage of the pandemic
Dual infections are quite common and sequences are "consensus" sequences (which exclude minor variants). The three polymorphisms in the Sao Paulo sequence trace to three different origins, and the synonymous polymorphism is in 8574-Argentina-2009-S4-HA-41.
ReplyDeletePA C1263T is also present in the following sequences (part1):
ReplyDeletegb|CY042601.1| A/ruddy turnstone/New Jerse
gb|CY042587.1| A/ruddy turnstone/New Jerse
gb|CY042578.1| A/ruddy turnstone/New Jerse
gb|CY042567.1| A/ruddy turnstone/New Jerse
gb|CY042563.1| A/ruddy turnstone/New Jerse
gb|CY042548.1| A/ruddy turnstone/Delaware/
gb|CY042538.1| A/ruddy turnstone/New Jerse
gb|CY042530.1| A/ruddy turnstone/New Jerse
gb|CY042526.1| A/ruddy turnstone/New Jerse
gb|CY042510.1| A/ruddy turnstone/New Jerse
gb|CY042491.1| A/ruddy turnstone/New Jerse
gb|CY042487.1| A/ruddy turnstone/New Jerse
gb|CY042484.1| A/ruddy turnstone/New Jerse
gb|CY042480.1| A/ruddy turnstone/New Jerse
gb|CY042472.1| A/ruddy turnstone/New Jerse
gb|CY042464.1| A/ruddy turnstone/New Jerse
gb|CY042461.1| A/ruddy turnstone/New Jerse
gb|CY042446.1| A/ruddy turnstone/New Jerse
gb|CY042436.1| A/ruddy turnstone/New Jerse
gb|CY042433.1| A/sanderling/New Jersey/Sg-
gb|CY042424.1| A/ruddy turnstone/New Jerse
gb|CY042418.1| A/ruddy turnstone/Delaware/
gb|CY042414.1| A/ruddy turnstone/Delaware/
gb|CY042409.1| A/ruddy turnstone/New Jerse
gb|CY042406.1| A/ruddy turnstone/Delaware/
gb|CY042166.1| A/blue-winged teal/Louisian
gb|CY042155.1| A/mallard/Minnesota/Sg-0018
gb|GQ257438.1| A/duck/New York/492652/2007
gb|GQ257452.1| A/mallard/Maryland/13/2003
gb|FJ784805.1| A/chicken/Hubei/3002/2007
gb|FJ784804.1| A/duck/Hubei/2911/2007(H5N1
gb|FJ784797.1| A/duck/Henan/1650/2006(H5N1
gb|FJ784793.1| A/duck/Hunan/689/2006(H5N1)
gb|FJ686719.1| A/mallard/Ohio/362/2003(H2N
gb|FJ686735.1| A/mallard/Ohio/365/2003(H2N
gb|FJ517299.1| A/mallard/Minnesota/354/199
dbj|AB434327.1| A/swine/Chachoengsao/NIAH5
dbj|AB434319.1| A/swine/Chonburi/NIAH589/2
gb|CY036631.1| A/duck/Massachusetts/Sg-004
gb|CY036552.1| A/unknown/New York/Sg-00420
gb|CY036545.1| A/unknown/New York/Sg-00418
gb|CY036509.1| A/unknown/New York/Sg-00409
gb|CY036060.1| A/crested goshawk/Hong Kong
gb|CY036052.1| A/scaly-breasted munia/Hong
gb|CY035351.1| A/mallard/Minnesota/Sg-0020
gb|CY035298.1| A/mallard/Minnesota/Sg-0017
gb|CY033768.2| A/mallard duck/Minnesota/Sg
gb|FJ357117.1| A/mallard/MD/26/2003(H1N1)
gb|FJ357125.1| A/mallard/MD/41/2003(H1N1)
gb|FJ357133.1| A/mallard/MD/42/2003(H1N1)
gb|FJ357141.1| A/mallard/MD/53/2003(H1N1)
gb|CY034644.1| A/blue-winged teal/Texas/Sg
gb|EU980506.1| A/mallard/MD/185/2003(H5N2)
gb|EU980513.1| A/mallard/MD/11/2003(H1N1)
gb|EU980521.1| A/mallard/MD/199/2003(H1N1)
gb|CY033767.1| A/mallard duck/Minnesota/Sg
gb|EU871897.1| A/mallard/MN/323/1999(H4N8)
gb|EU743200.1| A/chicken/NY/11602-12/1998
gb|EU743462.1| A/mallard/MN/42/2000(H11N9)
gb|EU743533.1| A/mallard/MN/280/1999(H3N5)
part 2 for PA C1263T
ReplyDeletegb|EU743132.1| A/duck/NY/191255-59/2002(H5
gb|EU743230.1| A/duck/NY/186875/2002(H5N2)
gb|EU182317.1| A/chicken/NY/14677-13/1998
gb|EU084951.1| A/Duck/NY/185502/2002(H5N2)
gb|EU026087.1| A/mallard/MD/403/2002(H1N1)
gb|CY022610.1| A/green-winged teal/Ohio/12
gb|CY021658.1| A/black duck/Ohio/161/1999
gb|CY021642.1| A/mallard/Delaware/418/2005
gb|CY021354.1| A/green-winged teal/Ohio/12
gb|CY021338.1| A/mallard/Maryland/1241/200
gb|CY021250.1| A/american black duck/Ohio/
gb|CY020922.1| A/environment/Ohio/1007/200
gb|CY020794.1| A/mallard/Ohio/668/2002(H4N
gb|DQ997128.1| A/chicken/Hubei/wk/1997(H5N
gb|CY015070.1| A/turkey/England/1963(H7N3)
gb|CY015057.1| A/chicken/Brescia/1902(H7N7
gb|CY015051.1| A/fowl/Rostock/45/1934(H7N1
gb|CY014996.1| A/fowl/Dobson/1927(H7N7)
gb|CY014893.1| A/duck/New York/16873/1999
gb|CY014885.1| A/chicken/New York/14677-13
gb|CY014676.1| A/chicken/Germany/n/1949(H1
gb|CY005820.1| A/duck/Czechoslovakia/1956
gb|CY005229.1| A/mallard/ALB/5/1995(H10N1)
gb|CY004908.1| A/blue-winged teal/ALB/293/
gb|CY004448.1| A/shorebird/DE/68/2004(H13N
gb|CY004916.1| A/mallard/ALB/49/1995(H4N6)
gb|AF285890.1| A/Swine/Ontario/019
emb|X17223.1| A/FPV/Rostock/34(H7N1)
gb|AY684885.1| A/black-headed gull/Sweden/
gb|AY684883.1| A/black-headed gull/Sweden/
emb|AJ243992.1| A/FOWL PLAGUE VIRUS
gb|M21850.1|FLAPACR A/chicken/FPV/Rostock/
One of the Argentina sequences, 9576-Argentina-2009-S3-PA-6, has an adjacent polymorphism, A1287G, which is found in a long list of avian and a few swine sequences, which largely match the list for C1263T, supporting acquistion via homologous recombination. Since, like C1263T, the list is long, I am just posting the link to the sequences, which is rather compelling.
ReplyDeletehttp://www.flutrackers.com/forum/showpost.php?p=274900&postcount=111
The Argentina sequence with PA A1287 is 8019-Argentina-2009-S3-PA-2 (incorectly stated in preceding post). Donor sequences which have C1263T and A1287G and exactly match the Argentina sequence at all postions between the two polymorphisms are:
ReplyDeletegb|CY042601.1| A/ruddy turnstone/New Jerse
gb|CY042587.1| A/ruddy turnstone/New Jerse
gb|CY042578.1| A/ruddy turnstone/New Jerse
gb|CY042567.1| A/ruddy turnstone/New Jerse
gb|CY042563.1| A/ruddy turnstone/New Jerse
gb|CY042548.1| A/ruddy turnstone/Delaware/
gb|CY042538.1| A/ruddy turnstone/New Jerse
gb|CY042530.1| A/ruddy turnstone/New Jerse
gb|CY042526.1| A/ruddy turnstone/New Jerse
gb|CY042510.1| A/ruddy turnstone/New Jerse
gb|CY042491.1| A/ruddy turnstone/New Jerse
gb|CY042487.1| A/ruddy turnstone/New Jerse
gb|CY042484.1| A/ruddy turnstone/New Jerse
gb|CY042480.1| A/ruddy turnstone/New Jerse
gb|CY042472.1| A/ruddy turnstone/New Jerse
gb|CY042464.1| A/ruddy turnstone/New Jerse
gb|CY042461.1| A/ruddy turnstone/New Jerse
gb|CY042446.1| A/ruddy turnstone/New Jerse
gb|CY042436.1| A/ruddy turnstone/New Jerse
gb|CY042433.1| A/sanderling/New Jersey/Sg-
gb|CY042424.1| A/ruddy turnstone/New Jerse
gb|CY042418.1| A/ruddy turnstone/Delaware/
gb|CY042414.1| A/ruddy turnstone/Delaware/
gb|CY042409.1| A/ruddy turnstone/New Jerse
gb|CY042406.1| A/ruddy turnstone/Delaware/
gb|CY042166.1| A/blue-winged teal/Louisian
gb|CY042155.1| A/mallard/Minnesota/Sg-0018
gb|GQ257438.1| A/duck/New York/492652/2007
gb|GQ257452.1| A/mallard/Maryland/13/2003
gb|FJ686719.1| A/mallard/Ohio/362/2003(H2N
gb|FJ686735.1| A/mallard/Ohio/365/2003(H2N
gb|FJ517299.1| A/mallard/Minnesota/354/199
dbj|AB434327.1| A/swine/Chachoengsao/NIAH5
dbj|AB434319.1| A/swine/Chonburi/NIAH589/2
gb|CY036631.1| A/duck/Massachusetts/Sg-004
gb|CY036552.1| A/unknown/New York/Sg-00420
gb|CY036545.1| A/unknown/New York/Sg-00418
gb|CY036509.1| A/unknown/New York/Sg-00409
gb|CY035351.1| A/mallard/Minnesota/Sg-0020
gb|CY035298.1| A/mallard/Minnesota/Sg-0017
gb|CY033768.2| A/mallard duck/Minnesota/Sg
gb|FJ357117.1| A/mallard/MD/26/2003(H1N1)
gb|FJ357125.1| A/mallard/MD/41/2003(H1N1)
gb|FJ357133.1| A/mallard/MD/42/2003(H1N1)
gb|FJ357141.1| A/mallard/MD/53/2003(H1N1)
gb|CY034644.1| A/blue-winged teal/Texas/Sg
gb|EU980506.1| A/mallard/MD/185/2003(H5N2)
gb|EU980513.1| A/mallard/MD/11/2003(H1N1)
gb|EU980521.1| A/mallard/MD/199/2003(H1N1)
gb|CY033767.1| A/mallard duck/Minnesota/Sg
gb|EU871897.1| A/mallard/MN/323/1999(H4N8)
gb|EU743533.1| A/mallard/MN/280/1999(H3N5)
gb|EU743132.1| A/duck/NY/191255-59/2002(H5
gb|EU743230.1| A/duck/NY/186875/2002(H5N2)
gb|EU084951.1| A/Duck/NY/185502/2002(H5N2)
gb|EU026087.1| A/mallard/MD/403/2002(H1N1)
gb|CY022610.1| A/green-winged teal/Ohio/12
gb|CY021658.1| A/black duck/Ohio/161/1999
gb|CY021642.1| A/mallard/Delaware/418/2005
gb|CY021354.1| A/green-winged teal/Ohio/12
gb|CY021338.1| A/mallard/Maryland/1241/200
gb|CY021250.1| A/american black duck/Ohio/
gb|CY020922.1| A/environment/Ohio/1007/200
gb|CY020794.1| A/mallard/Ohio/668/2002(H4N
gb|CY015070.1| A/turkey/England/1963(H7N3)
gb|CY014676.1| A/chicken/Germany/n/1949(H1
gb|CY005820.1| A/duck/Czechoslovakia/1956
gb|CY005229.1| A/mallard/ALB/5/1995(H10N1)
gb|CY004908.1| A/blue-winged teal/ALB/293/
gb|CY004448.1| A/shorebird/DE/68/2004(H13N
gb|CY004916.1| A/mallard/ALB/49/1995(H4N6)
gb|AF285890.1| A/Swine/Ontario/019
gb|AY684885.1| A/black-headed gull/Sweden/
gb|AY684883.1| A/black-headed gull/Sweden/
data not free, not public ?
ReplyDeleteI got them from a link at FT, no registration,
no restriction/agreement.
Now I read:
----------------
Given that these are draft (i.e., preliminary) data, and are subject to change, I agree not to forward the draft (i.e., preliminary) data to third parties, but will instead direct them to the website.
http://cii.columbia.edu/welcomeINEI.html
--------------------------
so the data are not public ?? (yet)
(which website ?)
now, do I have to unpost all what I said here
or in the forums ?
Do I have to remove them from my databases
(after spending hours to convert them) ?
ahh, really. I don't like that.
We had discussion about GISAID-policy before.
http://www.singtomeohmuse.com/viewtopic.php?t=2545
hopefully genbank will get the sequences soon
or others will provide sequences from South America
This comment has been removed by the author.
ReplyDeleteResearchers,
ReplyDeleteI am very grateful for your making these sequences from Argentina available so soon.
They are offering compelling study for myself and many others that will promote a beneficial accumulation of knowledge on the South American specimens and potentially the next wave in the Northern Hemisphere. Early data allows deeper analyses. Deeper analyses drive better collection and collaboration efforts.
Please continue to publish as available. Your academic generousity is presently yielding insight and allowing a more robust dataset for our team.
When do you expect to extend the data? Will you have clinical data or category identifiers at any point? Will you create a new dataset with the accumulated sequences or publish incremental updates?
Thank you for the sequences. Sensible researchers are benefiting.
Yes, the availbility of these sequences at an early date is most appreciated.
ReplyDeleteI think required registration for posting might help keep comments on the sequences more on topic.
Speaking of the sequences, the link for PB1 txt sequences returns MA sequences.
http://cii.columbia.edu/PB1_Alignment.txt
Dear colleagues,
ReplyDeleteThanks a lot for your comments and insights. We will be adding more sequences in the following days. We are still processing samples and isolates from the more severe cases of the outbreak in Argentina.
I hope to fix the link to the PB1 link ASAP.
-Gustavo Palacios
Gus,
ReplyDeleteThanks for the update. Are most of the samples from severe/fatal cases in the Buenos Aires / Santa Fe provinces, or do they cover a broader geographical area? The finding of C1263T in all PA sequences was a bit surprising.
Dear Gus and Colleagues,
ReplyDeleteExtending Dr. Niman's request, would you mind examining the links to NP, PA, PB1 and PB2 on the text based Alignment outcomes? Each of these appears to present the same Segment 7 results.
I begin to speculate that your team may focus on "universal" vaccine targets?
A third PA polymorphism, G1761A, is in 8019-Argentina-2009-S3-PA-2 and that polymorphism is also in many of the avian isolates with the C1263T and A1287A as well as the Candian swine (see list at link below), leaving little doubt that these polymorphisms were acquired by recombination.
ReplyDeletehttp://www.flutrackers.com/forum/showpost.php?p=276246&postcount=141
The CDC is releasing Argentina sequences at GISAID (mostly HA and NA and mostly isolates that have been released here).
ReplyDeleteThe CDC sequences were from isolates collected in mid-June and the sample numbers of the sequence released here suggest these sequences are also from mid-June, but most of the confirmed deaths in Argentina were in July. Are sequences from these July fatal cases going to be posted here soon?
ReplyDeleteAny updates on new sequences?
ReplyDeleteMedia reports cite sequences on 50 isolates from Argentina, but only the original 11 are available here. Are there plans to release the other 39?
ReplyDeletehttp://fluboard.rhizalabs.com/forum/viewtopic.php?f=5&t=60&start=0
no replies, no updates, so I assume that was it.
ReplyDeleteWell, maybe neighboring countries will publish something or travelors from Argentina
are sequenced elsewhere.
Or scientists publishing from Argentina
need to keep it secret until publishing,
so it remains exclusive. I don't understand
how that works but we often see that.
That could give 6 months - 2 years delay
until a paper is published in a journal
and typically the sequences are published
then at genbank.
Too late for this coming wave.
now we have speculation about a more virulent virus in Ukraine ...
ReplyDeleteAgain no public seuences.